2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118656
    Cannabicitran
    		Ligand
    Cannabicitran is a cannabinoid. Cannabicitran can decrease intraocular pressure in rabbits.
    Cannabicitran
  • HY-169820
    CE-178253 benzenesulfonate
    		Antagonist
    CE-178253 benzenesulfonate is a CB1 antagonist with central nervous system activity.
    CE-178253 benzenesulfonate
  • HY-124954
    MN-25
    		Agonist
    MN-25
  • HY-164817
    CB1/2 receptor-1
    		Agonist
    CB1/2 receptor-1 (compound 5.3) is a CB1/2 receptor agonist. CB1/2 receptor-1 can be used in angiogenesis research.
    CB1/2 receptor-1
  • HY-155741
    CB2 PET Radioligand 1
    CB2 PET Radioligand 1 (compound [18F]9) is a PET Radioligand targeting to hCB2 (Ki=7.7 nM). CB2 PET Radioligand 1 is prepared with Cu-mediated 18F-fluorination. CB2 PET Radioligand 1 shows high brain uptake in a murine model of neuroinflammation.
    CB2 PET Radioligand 1
  • HY-151107
    CBR Agonist-2
    		Agonist
    CBR Agonist-2 is a CB1 agonist (CB1R; CB1 ligand) with an EC50 and a Ki of 960 nM and 970 nM, respectively. CBR Agonist-2 is a promising tool for investigating the involvement of hCB1R in disorders associated with the endocannabinoid system.
    CBR Agonist-2
  • HY-121637
    IDFP
    IDFP (iso-Prdodecylfluorophosphonate) is a chemical affinity probe for the cannabinoid CB1 receptor.
    IDFP
  • HY-149645
    CB2 receptor antagonist 2
    		Antagonist
    CB2 receptor antagonist 2 (compound 39) is a potent antagonist of CB2 with an IC50 value of 0.33 μM. CB2 receptor antagonist 2 has strong interactions with L17, W6.48, V6.51, and C7.42.
    CB2 receptor antagonist 2
  • HY-121947
    1'-Naphthoyl-2-methylindole
    1'-Naphthoyl-2-methylindole (Compound 88) is a cannabinoid mimetics and an inhibitor for Win 55212-2, that inhibits 34% of [3H]Win 55212-2 binding to cannabinoid receptors at 3 μM.
    1'-Naphthoyl-2-methylindole
  • HY-153800A
    (R)-Monlunabant
    		Modulator
    (R)-Monlunabant ((R)-MRI-1891) is a CB1 receptor mediators for research of obesity and metabolic disease
    (R)-Monlunabant
  • HY-172434
    Rezosicone
    		Antagonist
    Rezosicone is the antagonist for cannabinoid CB1 receptor.
    Rezosicone
  • HY-130357
    15(S)-HETE Ethanolamide
    		Agonist
    15(S)-HETE Ethanolamide is a cannabinoid analog the CB1 receptor (Ki of 600 nM).
    15(S)-HETE Ethanolamide
  • HY-155336
    CB2R agonist 2
    		Agonist
    CB2R agonist 2 (compound cis-17-para) is a CB2R agonist.
    CB2R agonist 2
  • HY-147532
    CB2R probe 1
    CB2R probe 1 is a safe and green CB2R (cannabinoid 2 receptor) fluorescent probe with an Ki of 130 nM. CB2R probe 1 shows low cytotoxicity in cancer cells.
    CB2R probe 1
  • HY-134173
    Arachidonoyl ethanolamide phosphate
    		Agonist
    Arachidonoyl ethanolamide phosphate, an endocannabinoid, is an endogenous ligand for cannabinoid receptors in the central nervous system (CB1 subtype) and peripheral immune cells (CB2 subtype).
    Arachidonoyl ethanolamide phosphate
  • HY-10863S1
    Anandamide-d11
    Anandamide-d11 is deuterium labeled Anandamide. Anandamide is an immune modulator in the central nervous system acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55)[1][2].
    Anandamide-d<sub>11</sub>
  • HY-115428
    (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide
    		Agonist
    (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide (Compound 19) is the analogue of endogenous cannabinoid receptor ligand Anandamide (HY-10863). (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide shows weak binding affinity for CB1 and CB2 with Kis of both 21 μM.
    (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide
  • HY-172409
    CB1R antagonist 2
    		Antagonist
    CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056)-induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models.
    CB1R antagonist 2
  • HY-P1091A
    Hemopressin(human, mouse) TFA
    		Antagonist
    Hemopressin TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin TFA exerts antinociceptive action in inflammatory pain models.
    Hemopressin(human, mouse) TFA
  • HY-141411
    (Rac)-Zevaquenabant
    		Antagonist 99.20%
    (Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a cannabinoid receptor type 1 (CB1R)/iNOS antagonist, with a Ki of 5.7 nM for CB1R. (Rac)-Zevaquenabant is potential for the research of liver fibrosis.
    (Rac)-Zevaquenabant
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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